Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca handling of the sarcoplasmic reticulum
نویسندگان
چکیده
Department of Internal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Department of Life Science and Medical Bio-Science, Waseda University, Tokyo, Japan; Department of Medical Chemistry, Kyoto University Graduate School of Pharmaceutical Science, Kyoto, Japan; Department of Cell Biology and Molecular Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA; and Department of Medicine (Cardiology), New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
منابع مشابه
Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca2+ handling of the sarcoplasmic reticulum.
AIMS Sarcalumenin (SAR) is a Ca(2+)-binding protein expressed in the longitudinal sarcoplasmic reticulum (SR) of striated muscle cells. Although its Ca(2+)-binding property is similar to that of calsequestrin, its role in the regulation of Ca(2+) cycling remains unclear. METHODS AND RESULTS To investigate whether SAR plays an important role in maintaining cardiac function under pressure overl...
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Sarcalumenin (SAR), a Ca(2+)-binding protein located in the longitudinal sarcoplasmic reticulum (SR), regulates Ca(2+) reuptake into the SR by interacting with cardiac sarco(endo)plasmic reticulum Ca(2+)-ATPase 2a (SERCA2a). We have previously demonstrated that SAR deficiency induced progressive heart failure in response to pressure overload, despite mild cardiac dysfunction in sham-operated SA...
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Sarcalumenin (SAR), specifically expressed in striated muscle cells, is a Ca2+-binding protein localized in the sarcoplasmic reticulum (SR) of the intracellular Ca2+ store. By generating SAR-deficient mice, we herein examined its physiological role. The mutant mice were apparently normal in growth, health, and reproduction, indicating that SAR is not essential for fundamental muscle functions. ...
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